THE TOLERANCE LAB
Leveraging immunomodulatory biomaterials to engineer tolerance
JACQUELINE BURKE, PhD
tolerance
noun
1. a fair and respectful attitude or policy toward people whose opinions, beliefs, practices, racial or ethnic origins, etc., differ from one’s own
WE WELCOME ALL
2. interest in, concern for, and openness toward ideas, opinions, practices, etc., that are different from one’s own
WE CONSIDER ALL IDEAS
3. capacity to endure pain or hardship; endurance, fortitude, stamina
WE WORK HARD
4. the lack of or low levels of immune response to transplanted tissue or other foreign substance that is normally immunogenic
WE STRIVE FOR TOLERANCE
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Jacqueline Burke, PhD
Jacqueline Burke, PhD is a Research Assistant Professor of Biomedical Engineering at Northwestern University. Dr. Burke received a BS from Johns Hopkins in Biomedical Engineering, a Certificate in Management for Scientists and Engineers from the Kellogg School of Management, and a MS and PhD from Northwestern University in Biomedical Engineering. Dr. Burke leads the Tolerance Lab. Her goal is to provide an inclusive research environment for the development of next-generation polymeric immunomodulatory biomaterials. Dr. Burke pursues clinical translation of laboratory discoveries via entrepreneurial ventures, including SNC Therapeutics, Inc.
Research
Areas of interest: Autoimmune Diseases, especially Type 1 Diabetes, Transplant Tolerance, Ischemia-Reperfusion Injury
News
Mar 28, 2025. From Edmonton to Lantidra and beyond: immunoengineering islet transplantation to cure type 1 diabetes.
PhD Candidates Klug and Mbaye Receive Awards to Present at AAI and ADA
Mar 27, 2025. Arona received the AAI Trainee Award and will present an oral presentation at AAI. Natalie received the TGS Travel Award and will present posters at AAI and ADA. Have fun in Hawaii!
First Review Article Published
Mar 19, 2025. From Edmonton to Lantidra and beyond: immunoengineering islet transplantation to cure type 1 diabetes. Congrats to first author Arona!
PhD Candidate El Hadji Arona Mbaye Presents at the Autumn Immunology Conference
Nov 23, 2024. Subcutaneous Nanotherapy for Islet Transplantation Preserves Functional Protective Immunity. Congrats Arona!
Apr 29, 2025. Symposium on Translational Regenerative Engineering
The Tolerance Lab Presents Posters at Symposium on Translational Regenerative Engineering
Apr 29, 2025. Symposium on Translational Regenerative Engineering
Recent Publications
Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability
Rational Engineering of Islet Tolerance via Biomaterial-Mediated Immune Modulation
Phase-changing citrate macromolecule combats oxidative pancreatic islet damage, enables islet engraftment and function in the omentum
From Edmonton to Lantidra and beyond: immunoengineering islet transplantation to cure type 1 diabetes
PEOPLE
Xiaomin Zhang, MD
Research Assistant Professor/Microsurgeon
Szumo Wang, MS
Research Specialist
Natalie Klug
PhD Candidate, Biomedical Engineering
Arona Mbaye
PhD Candidate, Biomedical Engineering
Simseok Andrew Yuk, PhD
Post-doctoral Fellow (Nadig Lab)
Austin Chen
Medical Student, Feinberg School of Medicine
Ethan Lao
Undergraduate Student, Biomedical Engineering
Joshua Chansky, MS
Research Assistant
Octavius Louis
Undergraduate Student, Molecular Biochemistry & Biophysics, Illinois Institute of Technology
Collaborators & Funding Sources
Gallery
GET IN TOUCH
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The Tolerance Lab is located on the 11th floor of the Robert H. Lurie Medical Research Building on the Chicago campus of Northwestern University. To contact us, please email jacqueline.burke@northwestern.edu.
