THE TOLERANCE LAB

tolerance

noun

1. a fair and respectful attitude or policy toward people whose opinions, beliefs, practices, racial or ethnic origins, etc., differ from one’s own

WE WELCOME ALL

2. interest in, concern for, and openness toward ideas, opinions, practices, etc., that are different from one’s own

WE CONSIDER ALL IDEAS

3. capacity to endure pain or hardship; endurance, fortitude, stamina

WE WORK HARD

4. the lack of or low levels of immune response to transplanted tissue or other foreign substance that is normally immunogenic

WE STRIVE FOR TOLERANCE

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Jacqueline Burke, PhD

Jacqueline Burke, PhD is a Research Assistant Professor of Biomedical Engineering at Northwestern University. Dr. Burke received a BS from Johns Hopkins in Biomedical Engineering, a Certificate in Management for Scientists and Engineers from the Kellogg School of Management, and a MS and PhD from Northwestern University in Biomedical Engineering. Dr. Burke leads the Tolerance Lab. Her goal is to provide an inclusive research environment for the development of next-generation polymeric immunomodulatory biomaterials. Dr. Burke pursues clinical translation of laboratory discoveries via entrepreneurial ventures, including SNC Therapeutics, Inc.

Research

Areas of interest: Autoimmune Diseases, especially Type 1 Diabetes, Transplant Tolerance, Ischemia-Reperfusion Injury

News

Provide a short description of categories listed below.

PhD candidate El Hadji Arona Mbaye presents his work at the Autumn Immunology Conference

Oct 25, 2024. Northwestern BME attends the 2024 BMES Conference in Baltimore, MD.

The Tolerance Lab celebrates World Diabetes Day

Nov 19, 2024. November 14th is World Diabetes Days (also the inventor of insulin Fredrick Banting's Birthday). Blue is the color for diabetes awareness. (Did you know that November 16th is International Tolerance Day?)

Girl Power at Power Plant Live!

Nov 23, 2024. Subcutaneous Nanotherapy for Islet Transplantation Preserves Functional Protective Immunity.

Congrats Arona!

Con

Antioxidant Gel Preserves Islet Function after Pancreas Removal

June 7, 2024. Antioxidant Gel Preserves Islet Function after Pancreas Removal. Amanda Morris, Northwestern News

Recent Publications

Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability

Rational Engineering of Islet Tolerance via Biomaterial-Mediated Immune Modulation

Phase-changing citrate macromolecule combats oxidative pancreatic islet damage, enables islet engraftment and function in the omentum

PEOPLE

Xiaomin Zhang, MD

Research Assistant Professor/Microsurgeon

Szumo Wang, MS

Research Specialist

Natalie Klug

PhD Candidate, Biomedical Engineering

Arona Mbaye

PhD Candidate, Biomedical Engineering

Simseok Andrew Yuk, PhD

Post-doctoral Fellow (Nadig Lab)

Austin Chen

Medical Student, Feinberg School of Medicine

Ethan Lao

Undergraduate Student, Biomedical Engineering

Joshua Chansky, MS

Research Volunteer

Octavius Louis

Undergraduate Student, Molecular Biochemistry & Biophysics, Illinois Institute of Technology

Collaborators & Funding Sources

GET IN TOUCH

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The Tolerance Lab is located on the 11th floor of the Robert H. Lurie Medical Research Building on the Chicago campus of Northwestern University. To contact us, please email jacqueline.burke@northwestern.edu.